A*STAR scientists solve century-old mystery in yeast infections






SINGAPORE: Scientists from the Agency for Science Technology And Research (A*STAR) have solved a century-old mystery in yeast infections.

They constructed stable strains of Candida albicans, the most prevalent human fungal pathogen and a major cause of hospital acquired infection.

A*STAR said on Friday that their discovery will help pave the way to develop drugs that effectively target and treat such infections.

Currently, the choice of drugs for this pathogen is limited.

Drugs resistance has also emerged worldwide, posing a great challenge to medicine.

The A*STAR scientists have shown that Candida albicans, long thought of as always having two copies of each chromosome and no sexual reproduction in its life, can and does exist as a sexually reproducing cell carrying only one copy of its genome.

The discovery fills a long missing gap in the life cycle of the pathogen and greatly advances the understanding of how it generates genetic variations.

The tools developed will help speed up the analyses of gene function and might speed up efforts to cure Candida infections.

- CNA/fa



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Saibaba trust got Rs 275 crore donation in 2012

SHIRDI: The Saibaba Shirdi Sansthan Trust received a donation of Rs 274.71 crore from devotees last year, a senior trust official said.

Devotees also donated 36 kg of gold in various forms in 2012, estimated to be worth Rs 11 crore, Sansthan's executive officer Kishor More said yesterday.

However, the Sansthan received 373 kg of silver in the last calendar year, even as it received 440 kg of the metal in 2011, More said.

The Sansthan had recently melted the treasure's 37 kg gold and 513 kg silver for making coins while it still has about 300 kg gold and 4,000 kg silver with it, he said.

In 2011, the trust had received Rs 225.55 crore cash, while last year the cash donation increased by about 20 per cent, he said.

Out of the Rs 274.71 crore cash, Rs 57 crore was earned through the Sansthan's donation counters, Rs 180.74 crore through cash boxes and Rs 40 crore was received through cheques, online and money orders, More said.

Sansthan's fixed deposits with various nationalised banks in 2012 were worth Rs 803 crore, while deposits in 2011 were of Rs 580 crore.

Last year, there was also an increase in foreign exchange worth Rs 8.30 crore, while in 2011 it was Rs 6.28 crore, he added.

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Hedgehog Alert! Prickly pets can carry salmonella


NEW YORK (AP) — Add those cute little hedgehogs to the list of pets that can make you sick.


In the last year, 20 people were infected by a rare but dangerous form of salmonella bacteria, and one person died in January. The illnesses were linked to contact with hedgehogs kept as pets, according to a report released Thursday by the Centers for Disease Control and Prevention.


Health officials on Thursday say such cases seem to be increasing.


The CDC recommends thoroughly washing your hands after handling hedgehogs and cleaning pet cages and other equipment outside.


Other pets that carry the salmonella bug are frogs, toads, turtles, snakes, lizards, chicks and ducklings.


Seven of the hedgehog illnesses were in Washington state, including the death — an elderly man from Spokane County who died in January. The other cases were in Alabama, Illinois, Indiana, Michigan, Minnesota, Ohio and Oregon.


In years past, only one or two illnesses from this salmonella strain have been reported annually, but the numbers rose to 14 in 2011, 18 last year, and two so far this year.


Children younger than five and the elderly are considered at highest risk for severe illness, CDC officials said.


Hedgehogs are small, insect-eating mammals with a coat of stiff quills. In nature, they sometimes live under hedges and defend themselves by rolling up into a spiky ball.


The critters linked to recent illnesses were purchased from various breeders, many of them licensed by the U.S. Department of Agriculture, CDC officials said. Hedgehogs are native to Western Europe, New Zealand and some other parts of the world, but are bred in the United States.


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Online:


CDC report: http://www.cdc.gov/mmwr


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Arias' Lawyer Shows Ex-Boyfriend's Lewd Photos













Accused murderer Jodi Arias was kept away from the Mormon friends of her lover Travis Alexander and their torrid sex affair was kept secret by Alexander, even as he sent lewd photos of himself to her online, according to court testimony today.


The testimony in Arias' trial for killing Alexander in 2008 was intended to bolster the defense's argument that she killed him in self defense, that Alexander was a sexual deviant who treated Arias as his "dirty little secret."


Arias' attorneys introduced as evidence photos that Alexander took of his penis and sent to Arias, part of a string of graphic messages and sexual phone calls the two engaged in while Alexander, an elder in the Mormon church, was supposed to be chaste.


Today's witness was the latest in a string called by the defense, including Alexander's former girlfriend Lisa Daidone, who told the court that Alexander had professed to be a virgin.


Daniel Freeman continued his testimony today, describing how he was a friend of both Arias and Alexander but that Alexander kept Arias distanced from his Mormon pals.


"Travis had made more friends at (the Mormon) ward, and had (Ultimate Fighting Championship) fight nights at his house many times, and Jodi was in town, but she wasn't there," Freeman said.


"There was that group of friends, them and Jodi, two different groups, and so Lisa [Daidone] and friends from church were there, but Jodi wasn't there," Freeman said.










Jodi Arias Murder Trial: Former Boyfriend Takes Stand Watch Video









Jodi Arias Murder Trial: Defense's First Day of Witnesses Watch Video





Alexander's behavior, the defense hopes to prove, shows that he mistreated Arias.


Arias, 32, is on trial for murdering Alexander, whom she dated for a year and continued to have a sexual relationship for a year after that. Her attorneys claim that Alexander was abusive and controlling toward Arias, and that she was forced to kill him.


Freeman described how he took a trip with his sister, Alexander, and Arias, and how Alexander had asked him to come along so that he and Arias "would not get physical."


"I don't know that I can say he didn't want to be alone with her, but he liked that when I was there, and my sister was there. They weren't as physical," Freeman said.


Freeman admitted that he had no idea Alexander and Arias had been having a sexual relationship the entire time they were together. He said Alexander never mentioned that to his friends.


In fact, Freeman noted that Alexander was considered to be a church elder when he baptized Arias into the Church of Latter-Day Saints. Both a church elder and a convert were expected to abide by the church's strict law of chastity, which banned any sexual relations outside of marriage.


"One thing people give up in this baptism process was sex," prosecutor Juan Martinez said. "Did you know she was having oral sex with Mr. Alexander at the time of her baptism? Would that be an insincere baptism?"


"She would not be ready to be baptized in that case," Freeman said.


"You were asked about Miss Arias, whether she was worthy of baptism if she was performing oral sex, but what about the elder receiving oral sex?" defense attorney Kirk Nurmi said.


"They would not be worthy of performing that ordinance at that time until they had gone through repentance," Freeman said. "They would go to a discipline council and could face excommunication or a probation period or have their priesthood removed."


Freeman said that Alexander never confessed to having a sexual relationship with Arias.


Freeman's testimony came on the third day of the defense's attempt to paint Alexander as a controlling, sex-obsessed liar who was cruel to Arias. Other witnesses have said that Alexander cheated on other women he dated with Arias, and lied to his friends and family about their relationship.


The defense also had Freeman point out that Alexander was strong and fit. They are expected to conclude that Alexander was physically threatening Arias when she killed him.



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Syrian rebels make slow headway in south


AMMAN (Reuters) - The revolt against President Bashar al-Assad first flared in Deraa, but the southern border city now epitomizes the bloody stalemate gripping Syria after 22 months of violence and 60,000 dead.


Jordan next door has little sympathy with Assad, but is wary of spillover from the upheaval in its bigger neighbor. It has tightened control of its 370-km (230-mile) border with Syria, partly to stop Islamist fighters or weapons from crossing.


That makes things tough for Assad's enemies in the Hawran plain, traditionally one of Syria's most heavily militarized regions, where the army has long been deployed to defend the southern approaches to Damascus from any Israeli threat.


The mostly Sunni Muslim rebels, loosely grouped in tribal and local "brigades", are united by a hatred of Assad and range from secular-minded fighters to al Qaeda-aligned Islamists.


"Nothing comes from Jordan," complained Moaz al-Zubi, an officer in the rebel Free Syrian Army, contacted via Skype from the Jordanian capital Amman. "If every village had weapons, we would not be afraid, but the lack of them is sapping morale."


Insurgents in Syria say weapons occasionally do seep through from Jordan but that they rely more on arsenals they seize from Assad's troops and arms that reach them from distant Turkey.


This month a Syrian pro-government television channel showed footage of what it said was an intercepted shipment of anti-tank weapons in Deraa, without specifying where it had come from.


Assad's troops man dozens of checkpoints in Deraa, a Sunni city that was home to 180,000 people before the uprising there in March 2011. They have imposed a stranglehold which insurgents rarely penetrate, apart from sporadic suicide bombings by Islamist militants, say residents and dissidents.


Rebel activity is minimal west of Deraa, where military bases proliferate near the Israeli-occupied Golan Heights.


Insurgents have captured some towns and villages in a 25-km (17-mile) wedge of territory east of Deraa, but intensifying army shelling and air strikes have reduced many of these to ruin, forcing their residents to join a rapidly expanding refugee exodus to Jordan, which now hosts 320,000 Syrians.


However, despite more than a month of fighting, Assad's forces have failed to winkle rebels out of strongholds in the rugged volcanic terrain that stretches from Busra al-Harir, 37 km (23 miles) northeast of Deraa, to the outskirts of Damascus.


Further east lies Sweida, home to minority Druze who have mostly sat out the Sunni-led revolt against security forces dominated by Assad's minority, Shi'ite-rooted Alawite sect.


"KEY TO DAMASCUS"


As long as Assad's forces control southwestern Syria, with its fertile, rain-fed Hawran plain, his foes will find it hard to make a concerted assault on Damascus, the capital and seat of his power, from suburbs where they already have footholds.


"If this area is liberated, the supply routes from the south to Damascus would be cut," said Abu Hamza, a commander in the rebel Ababeel Hawran Brigade. "Deraa is the key to the capital."


Fighters in the north, where Turkey provides a rear base and at least some supply lines, have fared somewhat better than their counterparts in the south, grabbing control of swathes of territory and seizing half of Aleppo, Syria's biggest city.


They have also captured some towns in the east, across the border from Iraq's Sunni heartland of Anbar province, and in central Syria near the mostly Sunni cities of Homs and Hama.


But even where they gain ground, Assad's mostly Russian-supplied army and air force can still pound rebels from afar, prompting a Saudi prince to call for outsiders to "level the playing field" by providing anti-tank and anti-aircraft weapons.


"What is needed are sophisticated, high-level weapons that can bring down planes, can take out tanks at a distance," Prince Turki al-Faisal, a former intelligence chief and brother of the Saudi foreign minister, said last week at a meeting in Davos.


Saudi Arabia and its fellow Gulf state Qatar have long backed Assad's opponents and advocate arming them, but for now the rebels are still far outgunned by the Syrian military.


"They are not heavily armed, properly trained or equipped," said Ali Shukri, a retired Jordanian general, who argued also that rebels would need extensive training to use Western anti-tank or anti-aircraft weapons effectively even if they had them.


He said two powerful armored divisions were among Syrian forces in the south, where the rebels are "not that strong".


It is easier for insurgents elsewhere in Syria to get support via Turkey or Lebanon than in the south where the only borders are with Israel and Jordan, Shukri said.


Jordan, which has urged Assad to go, but seeks a political solution to the crisis, is unlikely to ramp up support for the rebels, even if its cautious policy risks irritating Saudi Arabia and Qatar, financial donors to the cash-strapped kingdom.


ISLAMIST STRENGTH


"I'm confident the opposition would like to be sourcing arms regularly from the Jordanian border, not least because I guess it would be easier for the Saudis to get stuff up there on the scale you'd be talking about," said a Western diplomat in Amman.


A scarcity of arms and ammunition is the main complaint of the armed opposition, a disparate array of local factions in which Islamist militants, especially the al Qaeda-endorsed Nusra Front, have come to play an increasing role in recent months.


The Nusra Front, better armed than many groups, emerged months after the anti-Assad revolt began in Deraa with peaceful protests that drew a violent response from the security forces.


It has flourished as the conflict has turned ever more bitterly sectarian, pitting majority Sunnis against Alawites.


Since October, the Front, deemed a terrorist group by the United States, has carried out at least three high-profile suicide bombings in Deraa, attacking the officers' club, the governor's residence and an army checkpoint in the city centre.


Such exploits have won prestige for the Islamist group, which has gained a reputation for military prowess, piety and respect for local communities, in contrast to some other rebel outfits tainted by looting and other unpopular behavior.


"So far no misdeeds have come from the Nusra Front to make us fear them," said Daya al-Deen al-Hawrani, a fighter from the rebel al-Omari Brigade. "Their goal and our goal is one."


Abu Ibrahim, a non-Islamist rebel commander operating near Deraa, said the Nusra Front fought better and behaved better than units active under the banner of the Free Syrian Army.


"Their influence has grown," he acknowledged, describing them as dedicated and disciplined. Nor were their fighters imposing their austere Islamic ideology on others, at least for now. "I sit with them and smoke and they don't mind," he said.


The Nusra Front may be trying to avoid the mistakes made by a kindred group, Al Qaeda in Iraq, which fought U.S. troops and the rise of Shi'ite factions empowered by the 2003 invasion.


The Iraqi group's suicide attacks on civilians, hostage beheadings and attempts to enforce a harsh version of Islamic law eventually alienated fellow Sunni tribesmen who switched sides and joined U.S. forces in combating the militants.


Despite the Nusra Front's growing prominence and its occasional spectacular suicide bombings in Deraa, there are few signs that its fighters or other rebels are on the verge of dislodging the Syrian military from its southern bastions.


Abu Hamza, the commander in the Ababeel Hawran Brigade, was among many rebels and opposition figures to lament the toughness of the task facing Assad's enemies in the south: "What is killing us is that all of Hawran is a military area," he said.


"And every village has five army compounds around it."


(Writing by Alistair Lyon; Editing by Alastair Macdonald)



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SK Group head gets four-year jail sentence






SEOUL: The head of South Korea's third largest conglomerate, the SK Group, was sentenced to four years in prison on Thursday after being convicted of embezzling close to $50 million.

The custodial sentence was seen as relatively tough in a country where convicted business tycoons are often given suspended prison terms in recognition of their apparent contribution to the national economy.

The court ruled that Chey Tae-Won, 53, had embezzled 49.7 billion won ($45.6 million) from two affiliates and funnelled the money into a firm for investments in stock futures and options in 2008.

The SK Group boss had remained free since he was indicted a year ago.

The energy-to-telecom conglomerate, which includes top mobile carrier SK Telecom, said Chey would appeal the verdict.

It was not Chey's first conviction.

In 2003 he was sentenced to three years in prison for his role in a $1.3 billion accounting fraud. He was released after just seven months and, in 2008, was finally granted a full presidential pardon, wiping his record clean.

It is not unusual for senior executives with convictions for crimes including tax evasion and embezzlement to remain in charge of South Korea's family-dominated conglomerates.

The Seoul Central District Court said in its statement that Chey had betrayed the public trust in his group.

"He should be reproached for using subsidiaries as a tool for his crime," it said.

Chey's younger brother and group vice chairman Chey Jae-Won was acquitted on charges that he was a knowing accomplice to the embezzlement.

South Korea has a long history of pardoning powerful tycoons.

Hyundai Motor head Chung Mong-Koo, who had been convicted of embezzlement and other charges, was pardoned in 2008, and Samsung Electronics chairman Lee Kun-Hee - convicted of tax evasion - was pardoned in 2009.

- AFP/de



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Six Congress MPs from Telangana firm on resignations

HYDERABAD: Six Congress MPs from Telangana on Thursday made it clear that they will not take back their resignations over the delay in formation of a separate state.

The MPs, who met here a day after reports of differences among them, claimed that resignations of seven MPs were Wednesday submitted to party president Sonia Gandhi's office.

However, Madhu Yaskhi Goud, later stated that there is no need for resignations as the party spokesperson has clarified that the party is not against Telangana state.

K. Rajagopal Reddy told reporters that Goud's views were his personal and that the remaining MPs stand by their resignations both from parliament and the party.

He said the resignations along with a letter addressed to Sonia Gandhi were sent to Delhi through Goud and another MP, Ponnam Prabhakar.

Reddy said they had requested Gandhi to accept their resignations if the party was unable to take a decision for formation of Telangana.

"We will continue to put pressure on the leadership till a favourable decision is taken," he added.

Senior leader K. Keshava Rao, at whose residence the meeting was held, said he would send his resignation from the party to Sonia Gandhi. He denied that there were any differences among the members.

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Sex to burn calories? Authors expose obesity myths


Fact or fiction? Sex burns a lot of calories. Snacking or skipping breakfast is bad. School gym classes make a big difference in kids' weight.


All are myths or at least presumptions that may not be true, say researchers who reviewed the science behind some widely held obesity beliefs and found it lacking.


Their report in Thursday's New England Journal of Medicine says dogma and fallacies are detracting from real solutions to the nation's weight problems.


"The evidence is what matters," and many feel-good ideas repeated by well-meaning health experts just don't have it, said the lead author, David Allison, a biostatistician at the University of Alabama at Birmingham.


Independent researchers say the authors have some valid points. But many of the report's authors also have deep financial ties to food, beverage and weight-loss product makers — the disclosures take up half a page of fine print in the journal.


"It raises questions about what the purpose of this paper is" and whether it's aimed at promoting drugs, meal replacement products and bariatric surgery as solutions, said Marion Nestle, a New York University professor of nutrition and food studies.


"The big issues in weight loss are how you change the food environment in order for people to make healthy choices," such as limits on soda sizes and marketing junk food to children, she said. Some of the myths they cite are "straw men" issues, she said.


But some are pretty interesting.


Sex, for instance. Not that people do it to try to lose weight, but claims that it burns 100 to 300 calories are common, Allison said. Yet the only study that scientifically measured the energy output found that sex lasted six minutes on average — "disappointing, isn't it?" — and burned a mere 21 calories, about as much as walking, he said.


That's for a man. The study was done in 1984 and didn't measure the women's experience.


Among the other myths or assumptions the authors cite, based on their review of the most rigorous studies on each topic:


—Small changes in diet or exercise lead to large, long-term weight changes. Fact: The body adapts to changes, so small steps to cut calories don't have the same effect over time, studies suggest. At least one outside expert agrees with the authors that the "small changes" concept is based on an "oversimplified" 3,500-calorie rule, that adding or cutting that many calories alters weight by one pound.


—School gym classes have a big impact on kids' weight. Fact: Classes typically are not long, often or intense enough to make much difference.


—Losing a lot of weight quickly is worse than losing a little slowly over the long term. Fact: Although many dieters regain weight, those who lose a lot to start with often end up at a lower weight than people who drop more modest amounts.


—Snacking leads to weight gain. Fact: No high quality studies support that, the authors say.


—Regularly eating breakfast helps prevent obesity. Fact: Two studies found no effect on weight and one suggested that the effect depended on whether people were used to skipping breakfast or not.


—Setting overly ambitious goals leads to frustration and less weight loss. Fact: Some studies suggest people do better with high goals.


Some things may not have the strongest evidence for preventing obesity but are good for other reasons, such as breastfeeding and eating plenty of fruits and vegetables, the authors write. And exercise helps prevent a host of health problems regardless of whether it helps a person shed weight.


"I agree with most of the points" except the authors' conclusions that meal replacement products and diet drugs work for battling obesity, said Dr. David Ludwig, a prominent obesity research with Boston Children's Hospital who has no industry ties. Most weight-loss drugs sold over the last century had to be recalled because of serious side effects, so "there's much more evidence of failure than success," he said.


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Online:


Obesity info: http://www.cdc.gov/obesity/data/trends.html


New England Journal: http://www.nejm.org


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Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP


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U.N.'s Ban decries "horrors" in Syria, urges end to war


KUWAIT (Reuters) - Denouncing "unrelenting horrors" in Syria's war, U.N. Secretary-General Ban Ki-moon appealed on Wednesday for an end to the violence and urged more aid to address a situation he said was catastrophic and worsening by the day.


"How many more people will be killed if the current situation continues?," Ban said, speaking at a conference of donors in Kuwait called to drum up more pledges of financing for U.N. humanitarian efforts.


"I appeal to all sides and particularly the Syrian government, to stop the killing ... in the name of humanity, stop the killing, stop the violence," he said.


More than 60,000 people have been killed since the 22-month-old conflict began, the United Nations says.


The world body warned on Monday that without more money it would not be able to help millions of Syrians and appealed for donations at the aid conference to meet its $1.5 billion target.


Some four million Syrians inside the country need food, shelter and other aid and more than 700,000 more have escaped to neighboring countries since the conflict began, according to the United Nations.


SCALE OF CRISIS ESCALATES


Jordan's King Abdullah told the gathering that Syrians had taken refuge in his country in their hundreds of thousands but Jordan's ability to help was at its limits.


"We have reached the end of the line, we have exhausted our resources," he said.


U.N. humanitarian chief Valerie Amos said farming was in crisis, hospitals and ambulances had been damaged and even painkillers were unavailable.


Harsh winter weather had made matters worse, and people were without winter clothes, blankets and fuel. Women and children were particularly at risk, she said. She added:


"We are watching a human tragedy unfold before our eyes."


The conference will seek pledges of $1 billion of aid for Syria's neighbors hosting refugees and another $500 million to fund humanitarian work for 4 million Syrians inside the country.


The aid would fund operations for the first half of this year, but the United Nations has so far received pledges covering just 18 percent of the target, unveiled last month as the scale of Syria's humanitarian crisis escalated sharply.


Even if pledges are made, aid groups have found in the past that converting promises into hard cash can take time.


Nevertheless, there was early positive news for the gathering when Kuwait and the United Arab Emirates each pledged to give $300 million to the aid effort.


Kuwait's emir, Sheikh Sabah al-Ahmad al-Sabah, told the meeting "horrifying reports" of violence had raised questions over the future of Syria and aid efforts had to be redoubled.


SEXUAL VIOLENCE, DETENTIONS


But Ban said much more remained to be done.


"The situation in Syria is catastrophic and getting worse every day," he said. "Every day Syrians face unrelenting horrors," he said, adding this included sexual violence and detentions.


Aid officials hope the fact that the conference is being held in Kuwait will encourage other wealthy Gulf Arab states, who have led regional opposition to President Bashar al-Assad, to support the international aid effort.


Many Gulf states have sent assistance, but aid workers say their efforts have been haphazard and rarely coordinated with other aid agencies, hampering their ability to plan a sustained relief program.


Syria's main opposition coalition has criticized the U.N. appeal and its arrangements for distributing aid inside Syria, saying the organization has effectively ceded control to the Syrian government and failed to deliver all but a bare minimum of aid to areas controlled by Assad's opponents.


(Reporting by Sylvia Westall, Ahmed Hagagy, Sami Aboudi, Mahmoud Habboush and Mirna Sleiman, Writing by William Maclean; Editing by Jon Boyle)



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S'pore moves up to 2nd spot in trust survey






SINGAPORE: Singapore has moved up to the number two spot for the most trusting nation in the world, according to the 2013 Edelman Trust Barometer. It was third in 2012 and seventh in 2011.

Edelman, which measured levels of trust in institutions in 26 countries worldwide, said on Wednesday that Singapore's total trust score rose by nine points and is three points more than the global average increase.

Trust levels rose across three of the four institutions measured -- business (up 11 points), non-governmental organisations (up 11 points) and government (up 9 points).

At 82 per cent, trust in Singapore government recovered to approach the 2010 high of 84 per cent.

Trust levels in the media remained stable and high.

Edelman said while the government and business fared well in the latest trust survey, there remains scepticism about trust in their leadership.

Only 19 per cent of Singaporeans in the general population trust business leaders to tell the truth, no matter how complex or unpopular it is. While trust in government leaders is higher than in business leaders, there remains room for improvement.

Edelman said the lack of trust in leaders, compared with the institutions they lead, is a trend in all the markets where trust was measured. This, it said, points to a common need to increase transparency at the leadership level.

-CNA/ac



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